Autologous Platelet Concentrates (PRF, A-PRF, i-PRF, CGF)

• What they are: Prepared from the patient’s own blood; contain growth factors (PDGF, TGF-β, VEGF) within a fibrin scaffold → help modulate wound healing.

• Main Benefits (based on systematic reviews):

  • Improve soft-tissue outcomes → increased thickness, wider keratinized mucosa, faster early healing.

  • Can aid bone healing (density, graft integration), though gains are modest if used alone.

• Specific Uses:

  • Maxillary Sinus Augmentation: CGF (alone or with grafts) may enhance blood supply and new bone formation. A-PRF+ + biomaterials = better graft integration and implant stability.

  • Peri-implant Soft Tissue: PRF can provide results similar to free gingival grafts for thickness/keratinized tissue. Grafts may still be superior in some measures, but PRF offers less pain, faster recovery, and lower cost.

• Limitations:

  • Strongest evidence = soft tissue and early healing benefits.

  • Less predictable for large bone volume gain if used alone.

  • Evidence quality is variable (many small, heterogeneous RCTs).

• Clinical Takeaway:
  PRF/CGF are adjunctive tools—not replacements for grafting when significant bone volume is required. Case selection, standardized protocols (e.g., spin settings), and realistic expectations are essential.